Research
PEER-REVIEWED RESEARCH:
Head, E., et. al. A combination Cocktail Improves Spacial Attention in a Canine Model of Human Aging and Alzheimer’s Disease. Journal of Alzheimer’s Disease. 32:2012, 1029-1042 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006672/
McGeer, E. G., McGeer, P.L. Neuroinflammation in Alzheimer’s Disease and Mild Cognitive Impairment: A field in its infancy. Journal of Alzheimer’s Disease. 19:2010, 355-361. https://www.deepdyve.com/lp/ios-press/neuroinflammation-in-alzheimer-s-disease-and-mild-cognitive-impairment-KdCF1c4z2m
Colman, C. W., Head, E. The Canine (dog) Model of Human Aging and Disease: Dietary, environmental and immunotherapy approaches. 15:2008, 685-707. https://www.researchgate.net/publication/23677126_The_Canine_Dog_Model_of_Human_Aging_and_Disease_Dietary_Environmental_and_Immunotherapy_Approaches
Head, E., et. al. Effects of Age, Dietary, and Behavioral Enrichment on Brain Mitochondria in a Canine Model of Human Aging. Experimental Neurology. 220:2009, 171-176. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761532/
Lim, G. P., et. al. The Curry Spice Curcumin reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse. Journal of Neuroscience. 21:2001, 8370-8377. http://www.jneurosci.org/content/21/21/8370
Tei, M. et. al. The Binding of Curcumin to Various Types of Canine Amyloid Proteins. Journal of Veterinary Medical Science. 74:2012, 481-483. https://www.jstage.jst.go.jp/article/jvms/74/4/74_11-0420/_article
Garcia-Alloza, M., et. al. Curcumin Labels Amyloid Pathology in Vivo Disrupts Existing Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer’s Brain. Journal of Veterinary Medical Science. 74:2007, 1095-1104. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2007.04613.x
Yang, F., et. al. Curcumin Inhibits Formation of Amyloid Beta Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo. Journal of Biological Chemistry. 280:2005, 5892-5901. http://www.jbc.org/content/280/7/5892.full
Zhang, C., et. al. Curcumin Decreases Amyloid-beta Peptide Levels by Attenuating the Maturation of Amyloid-beta Precursor Protein. Journal of Biological Chemistry. 285:2010, 28472-28480. https://www.researchgate.net/publication/45151063_Curcumin_Decreases_Amyloid-_Peptide_Levels_by_Attenuating_the_Maturation_of_Amyloid-_Precursor_Protein
Shoba, G., et. al. Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Medica. 64:1998, 353-356. https://www.ncbi.nlm.nih.gov/pubmed/9619120
Vijayakumar, R. S., et. al. Antioxidant Efficacy of Black Pepper (Piper Nigrum L.) and Piperine in Rats with High Fat Diet Induced Oxidative Stress. Redox Report. 9:2004, 105-110. https://www.tandfonline.com/doi/abs/10.1179/135100004225004742
Chonpathompikunlert, P., et. al. Piperine, the Main Alkaloid of Thai Black Pepper, Protects Against Neurodegeneration and Cognitive Impairment in Animal Model of Cognitive Deficit like Condition of Alzheimer’s Disease. Food and Chemical Toxicology. 48:2010, 798-802. http://www.academia.edu/3739436/Piperine_the_main_alkaloid_of_Thai_black_pepper_protects_against_neurodegeneration_and_cognitive_impairment_in_animal_model_of_cognitive_deficit_like_condition_of_Alzheimer_s_disease
Taisuke Ono, et. al. Curcumin Ameliorates Skeletal Muscle Atrophy in Type One Diabetic Mice by Inhibiting Protein Ubiquitination. Experimental Physiology. 100.9:2015, 1052-1063. https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/EP085049
Chiu, J., et. al. Curcumin Prevents Diabetes-associated Abnormalities in Kidneys by Inhibiting p300 and Nuclear Factor-kB. Nutrition. 25:2009, 964-972. https://www.sciencedirect.com/science/article/pii/S0899900709000069
Epstein, J., et. al. Curcumin as a Therapeutic Agent: The evidence from in vitro animal and human studies. British Journal of Medicine.i 103:2010, 1545-1557. https://www.researchgate.net/publication/41138694_Curcumin_as_a_therapeutic_agent_The_evidence_from_in_vitro_animal_and_human_studies
Jobin, C., et. al. Curcumin Blocks Cytokine-mediated NF-kB Activation and Pro-inflammatory Gene Expression by Inhibiting Inhibitory Factor I-kB Kinase Activity. Journal of Immunology. 163:1999, 3474-3483. http://www.jimmunol.org/content/163/6/3474
Clutterbuck, A. L., et. al. Interleukin-1B Induced Extracellular Matrix Degradation and Glycosaminoglycan Release is Inhibited by Curcumin in an Explant Model of Cartilage Inflammation. Annals of the New York Academy of Sciences. 1171:2009, 428-435. https://www.researchgate.net/publication/26782551_Interleukin-1b-Induced_Extracellular_Matrix_Degradation_and_Glycosaminoglycan_Release_Is_Inhibited_by_Curcumin_in_an_Explant_Model_of_Cartilage_Inflammation